Veranderingen in plaspatroon en kwaliteit van leven bij kinderen met plasproblemen die een behandeling met Botox krijgen.

Dysfunctional voiding (DV) is a term used for nonneurogenic increased urethral sphincter or pelvic floor muscle activity during voluntary voiding. The result is a lack of coordination between the detrusor muscle and the urethral sphincter. This results in either symptoms of urinary incontinence (UI), urinary tract infections (UTIs), or high post-void residual (PVR). A substantial group of children with DV, 10-40%, remains therapy-refractory. This group of children currently receives BoNT-A injections in the external urethral sphincter at Erasmus MC - Sophia as standard care. In a retrospective analysis performed by the investigators of the current protocol BoNT-A treatment has shown to be an effective and safe treatment option.



Children will receive BoNT-A treatment as standard care. Changes in voiding pattern and quality of life will be determined at predetermined time points based on uroflowmetry, dipstick analysis, PVR determination, voiding diaries, and questionnaires.



This patient group has an average of 6 outpatient visits per year as part of standard care. During the last study visit they will perform an extra uroflowmetry and keep a voiding diary for two days similar to the other five outpatient visits. Patients will be asked to fill out two questionnaires, which are not part of standard care, at seven time points. They are asked to keep a voiding diary for two days at seven time points, including for telephone contact. This is one extra time compared to standard care.

To assess the change in voiding pattern and quality of life in children who receive BoNT-A treatment in a prospective setting.

Baseline, 2 weeks after baseline, week 0, week 2, week 6, 3 months, 6 months, 9 months, 12 months.

Not applicable: study is observational.