Het effect van voedingsproducten met verschillende combinaties van groenten en fruit op de gezondheid van de mens

The effect of food products containing different combinations of vegetables and fruits on human health

The main objective of the human dietary intervention study is to investigate the beneficial health effects of food products containing various combinations of an equivalent of 400 grams vegetables and fruits in healthy volunteers. This will be evaluated in different subgroups with specific genetic characteristics on the level of different phenotypical markers, combined with gene expression profiling.

3 timepoints:

- baseline

- post-intervention 1

- post-intervention 2

A dietary intervention study will be performed to establish the beneficial health effects of 9 different food products, produced by MiFood (a company involved in food production industry (www.mifood.nl)), containing various combinations of phytochemicals from different combinations of vegetables and fruits. Seven of these 9 different food products will consist of a smoothie, containing different combinations of vegetables and fruits. Smoothies 1-4 will contain a specific selection of vegetables and fruit resulting in an overrepresentation of a specific class of phytochemicals. Smoothies 5-7 will consist of a combination of the four different classes overrepresented in smoothies 1-4, with increasing botanical diversity. Per day, each subject will consume 4 bottles of smoothies spread over the day, containing an equivalent of in total 400 grams vegetables and fruits.The remaining two dietary interventions will test a crouton (also called pearl), consisting of a core of oats and rice flour, either coated or non-coated with the most diverse mixture of vegetables and fruits as used in dietary intervention number 7.