Effecten van oligofructose (OF) supplementen op lichaamsgewicht en lichaamssamenstelling

Rationale: Based upon fermentation processes in the intestinal tract, food containing soluble dietary fibres, such as inulin or oligofructose, may limit energy intake and decrease adiposity in humans.
Objective: To study the effect of 12 weeks of supplementation of oligofructose at a dosage of 16 g/d versus placebo on body weight and body composition in overweight and obese men and women.

Study design: A 12 week, double-blind, randomized placebo-controlled parallel study. The study population will be randomly assigned to receive one of two interventions: 1) control granola bar (no oligofructose) or 2) granola bar with added oligofructose (16 g/d). Body weight, body composition, energy intake and appetite will be measured during the study, as well as gastrointestinal function and overall acceptability of the intervention.
Study population: 60 healthy males and females aged 20 – 60 y with a BMI > 25 kg/m2.

Intervention: Subjects receive either 16 g oligofructose or no oligofructose daily for 12 weeks. The dietary supplement will be consumed as a granola bar twice a day (8 g of oligofructose or no oligofructose per bar).

Main study parameters/endpoints: Difference in change of body weight and fat mass between control and oligofructose group after 12 weeks of supplementation.

Het lichaamsgewicht van mensen die 12 wk lang hun snacks vervangen voor muesli repen met toegevoegd OF zullen een lager lichaamsgewicht hebben dan mensen die 12 wk hun snack vervangen door een muesli reep zonder OF.

0, 1, 6, 12 wk

Subjects receive either 16 g oligofructose or no oligofructose daily for 12 weeks. The dietary supplement will be consumed as a granola bar twice a day (8 g of oligofructose or no oligofructose per bar).