We hypothesize that patients with symptoms of inability to belch have ineffective UES relaxation in response to esophageal distention caused by air.
ID
Bron
Verkorte titel
Aandoening
Inability to belch
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
the ability of UES relaxation in response to esophageal distention caused by ingested air as assessed with stationary high-resolution impedance manometry
Achtergrond van het onderzoek
Inability to belch is a phenomenon of unknown aetiology. Patients may present with lifelong symptoms of chest pain and/or abdominal bloating. As the phenomenon is quite rare and barely described in literature, there are no current guidelines or supporting evidence for a standardized diagnostic or therapeutic approach in these patients. A recent study treated patients unable to belch with botulin toxin (botox) injection into the cricopharyngeus muscle. All patients were able to belch and reported symptom improvement after treatment, which might indicate a role of upper esophageal sphincter (UES) dysfunction. However, belching and underlying mechanisms have never been objectively investigated in a series of consecutive patients unable to belch. The aim of this study is to reveal the underlying physiological mechanisms associated with symptoms of inability to belch and to study the effect of UES botox injections on UES physiology.
Doel van het onderzoek
We hypothesize that patients with symptoms of inability to belch have ineffective UES relaxation in response to esophageal distention caused by air.
Onderzoeksopzet
Baseline and <6 weeks >3 months post botox injections
Onderzoeksproduct en/of interventie
High-resolution impedance manomotry monitoring before the scheduled botox treatment
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Written informed consent;
- Age above 18 years;
- Complains of inability to belch, for at least 3 months.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Previous treatment for inability to belch
- History of pharyngeal or esophagal surgery or malignancies
- Use of medication affecting esophageal motility
Opzet
Deelname
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| Register | ID |
|---|---|
| NTR-new | NL8494 |
| Ander register | METC AMC : W19_307#19.365 |