Cannabis users with and without psychotic illness differ in CB1 receptor availability in striatal and extrastriatal regions as measured with PET and [18F] MK9470
ID
Bron
Verkorte titel
Aandoening
Cannabis use
Psychotic illness
Ondersteuning
UZ Gasthuisberg en Katholieke Universiteit Leuven, Belgium
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Striatal and extrastriatal [18F]MK9470 binding.
Achtergrond van het onderzoek
The study aims at contributing to the investigation of the biological mechanism behind the cannabis-psychosis relationship. In order to be able to prevent and to better treat psychotic illness, it is of crucial importance to understand the biological pathway through which THC may be causally related to psychosis, and to identify factors that may moderate this pathway. The distribution of CB1 receptors in dopamine-rich regions, such as the striatum, and dopaminergic projection areas, such as the prefrontal cortex, constitutes a prime candidate. By using PET and [18F]MK9470, striatal and extrastriatal CB1 receptor availability is measured in cannabis users with and without psychotic illness.
Doel van het onderzoek
Cannabis users with and without psychotic illness differ in CB1 receptor availability in striatal and extrastriatal regions as measured with PET and [18F] MK9470
Onderzoeksopzet
One timepoint (t0)
Onderzoeksproduct en/of interventie
PET and [18F]MK9470, a CB1 receptor ligand as a measure of CB1 receptor availability in vivo.
Publiek
Department of Psychiatry and Neuropsychology <br>
PO Box 616 (loc. Vijverdal.)
Cecile Henquet
Maastricht 6226 NB
The Netherlands
+31 (0)43 3688664
cecile.henquet@sp.unimaas.nl
Wetenschappelijk
Department of Psychiatry and Neuropsychology <br>
PO Box 616 (loc. Vijverdal.)
Cecile Henquet
Maastricht 6226 NB
The Netherlands
+31 (0)43 3688664
cecile.henquet@sp.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age 18-50 years
2. Life-time use of cannabis without having experienced negative effects
3. Being capable to consent and having signed informed consent
4. BMI between 18.5 and 27
5. Clinical diagnosis of non-affective psychosis according to DSM-IV (applies only to patients)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Head trauma with loss of consciousness of more than 1 hour
2. Respiratory, cardiovasculatory, neurological disease, severe renal or liver dysfunction
3. Alcohol use in excess of 5 units per day
4. Weekly use of illicit drugs other than cannabis
5. Current use of antipsychotic medication or medication known to interfere with the CB1 receptor
6. Pregnancy and breast-feeding
7. Personal or family history of psychosis (applies only to controls)
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1379 |
| NTR-old | NTR1439 |
| Ander register | : 2008-02 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |