We expect that the disproportionally strong clinical effects of fingolimod in relapsing remitting multiple sclerosis can be explained by enhanced functional adaptation mechanisms of the brain and that enhanced functional adaptation will be sustained…
ID
Bron
Aandoening
multiple sclerosis, functional magnetic resonance imaging, cognition, functional brain adaptation
multiple sclerose, functionele MRI, cognitie, functionele brein adaptatie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Improved neuropsychological test performance<br>
- Changed functional MRI/connectivity<br>
- Improved cognitive well-being
Doel van het onderzoek
We expect that the disproportionally strong clinical effects of fingolimod in relapsing remitting multiple sclerosis can be explained by enhanced functional adaptation mechanisms of the brain and that enhanced functional adaptation will be sustained over time
Onderzoeksopzet
baseline, 6 months and 18 months
Onderzoeksproduct en/of interventie
(functional) magnetic resonance imaging and neuropsychological testing
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Subjects should be between 18 and 65 years of age
- Subjects should meet the safety criteria to undergo MRI examination
- Patients should be diagnosed with RRMS
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Presence or history of psychiatric or neurological disease (for patients: neurological disease other than MS)
- Presence or history of drug abuse
- For patients: relapse or steroid treatment less than four weeks prior to examination
- Insufficient visual acuity and motor skills to perform the fMRI task
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4522 |
| NTR-old | NTR4657 |
| Ander register | Novartis : CFTY720DNL02T |