Het effect van een suikerbelasting op de vaatwand van de aorta.

Study of the effects of postprandial hyperglycemia in patients with impaired fasting glucose versus matched controls on aortic elasticity measured by the pulse wave velocity and heart rate variability.

Postprandial hyperglycemia has a negative effect on aortic elasticity in patients with impaired fasting glucose versus matched controls.

2 study days separated by 7-day intervals.

Each study day will consist of approximately 5 hours. For the study protocol the total examination time will be 80 minutes for the first MRI scan and 60 for the second MRI scan.

Subjects will arrive after an overnight fast. A cannula will be inserted for blood drawing during the MRI scan. MRI scan will be performed to measure baseline cardiac function, abdominal waist fat and pulse wave velocity. After this MRI scan heart rate variability will be measured by a 5 minurte ECG registration. Subsequently the patient will drink on one study day a 75g oral carbohydrate load (75g dextrose in 300 ml water) and on the other study day only 300 ml water as contol. At 30, 60, 90 and 120 minutes post-carbohydrate load, blood samples will be collected for insulin and glucose levels. Post-carbohydrate MRI evaluation of pulse wave velocity is performed at one or two hours after the carbohydrate load. Heart rate variability will me measured again immediately after the MRI scans. Optimal time of measurement will be defined in six patients.