Near-infrared fluorescence imaging of liver metastases is associated with radical resection margins.
ID
Bron
Verkorte titel
Aandoening
Neuroendocrine liver metastases
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To determine the radical resection rate.
Achtergrond van het onderzoek
Up to 40-50% of patients with neuroendocrine neoplasms (NEN) present themselves with metastases, of which 75-80% with liver metastases (NELM) [1, 2]. Near-infrared fluorescence detection using indocyanine green dye (ICG) aids in differentiating between normal liver tissue and malignant lesions, and identifies previously unknown sub-centimetre lesions in up to 17% of patients [3-5]. Intraoperative fluorescence detection of liver metastases has been described as a safe technique to detect additional lesions and aids the surgeon to find the optimal resection line. In this prospective study we aim to correlate fluorescence findings to radical resection rates after resection of NELM.
Doel van het onderzoek
Near-infrared fluorescence imaging of liver metastases is associated with radical resection margins.
Onderzoeksopzet
Baseline, 12 months
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Age of 18 years and older;
• All patients undergoing surgery for NELM;
• Patients eligible for ICG infusion 24h prior to surgery according to the hospital protocol.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Allergy to ICG, iodide or sodium iodide;
• Hyperthyroidism or benign thyroid tumour;
• Thyroid examination using radioactive iodide <1 week;
• Breast-feeding;
• No informed consent.
Opzet
Deelname
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| Register | ID |
|---|---|
| NTR-new | NL8802 |
| Ander register | METC AMC : W20_027 # 20.073 |