We hypothesize that information from metabolic processes in the paediatric brain tumour and surrounding tissue will help to understand tumour physiology, which will improve diagnosis and treatment evaluation.
ID
Bron
Verkorte titel
Aandoening
ow grade glioma (LGG) and diffuse pontine glioma (DIPG)
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect
changes in phospholipids and APT levels in paediatric brain tumours
Achtergrond van het onderzoek
Brain tumours are one of the leading causes of death in children. If possible, removing the tumour by surgery followed by radiotherapy and/or chemotherapy is nowadays the proposed treatment. But often the tumour cannot be removed and only chemo and/or radiation therapy are considered as treatment. During the treatment patients are monitored with structural imaging to evaluate response to therapy and its disease free survival. However, changes seen on imaging do not always reflect a change in tumour behaviour or growth; it might also reflect a reaction of the surrounding normal brain tissue on the treatment. From a diagnostic perspective, we are lacking a tool that can non-invasively identify tumour activity and indicate the aggressiveness of that piece of tumour. Information from metabolic processes in the tumour and surrounding tissue will help to understand tumour physiology, which will improve diagnosis and treatment evaluation, and may even help in choosing treatment strategy.
Objective: To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect changes in phospholipids and APT levels in paediatric brain tumours
Doel van het onderzoek
We hypothesize that information from metabolic processes in the paediatric brain tumour and surrounding tissue will help to understand tumour physiology, which will improve diagnosis and treatment evaluation.
Onderzoeksopzet
01-03-2020: start inclusion
01-09-2021: end inclusion
01-03-2022: end study
Onderzoeksproduct en/of interventie
MRI at 7T
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Children, 5-18 years diagnosed with a possible low grade glioma (LGG) or diffuse pontine glioma (DIPG)
- Children must be able to undergo MRI without anaesthesia;
- Informed and having given informed consent (either by patient and / or parents / legal guardian).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- The presence of claustrophobia;
- Patients from who it is known at the time of inclusion that they will undergo tumour resection within 1 month;
- MRI-specific exclusion criteria, such as metal implants. Screening for MRI specific exclusion criteria will be done using the regular MRI (at 7 Tesla) safety screening.
- Refusal or inability to provide informed consent by patient and / or parent / legal guardian.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8285 |
| Ander register | METC Utrecht : METC 19/791 |