To test if intensive control (SBP ¡Ü120 mmHg) decreases cerebral blood flow velocity compared to conventional targets (SBP
ID
Bron
Verkorte titel
Aandoening
Hypertension
Cerebral Small Vessel Disease (CSVD)
Hypertensie
Cerebrale wittestofschade
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
cerebral blood flow velocity
Achtergrond van het onderzoek
Pilot trial testing the effect of intensive control (SBP ≤120 mmHg) versus conventional targets (SBP<140-150 mmHg) on cerebral blood flow velocity in older (≤ 65 yrs) hypertensive patients with cerebral small vessel disease. Secondary objectives are to test the effect of tight blood pressure control on cognitive functioning, degree of white matter lesions and unacceptable side-effects of antihypertensive drugs.
Doel van het onderzoek
To test if intensive control (SBP ¡Ü120 mmHg) decreases cerebral blood flow velocity compared to conventional targets (SBP<140-150 mmHg) in PB in patients with CSVD and hypertension.
Onderzoeksopzet
baseline, after 4 months of follow-up
Onderzoeksproduct en/of interventie
intensive control (SBP ≤120 mmHg)
Publiek
Emma Kleipool
De Boelelaan 1117
Amsterdam 1081 HV
The Netherlands
020 444 2758
e.kleipool@vumc.nl
Wetenschappelijk
Emma Kleipool
De Boelelaan 1117
Amsterdam 1081 HV
The Netherlands
020 444 2758
e.kleipool@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• ≥ 65 years of age
• High systolic blood pressure of 150-200mmHg based on the average of a daytime 24-hour BP (with or without taking antihypertensive medication)
• Cerebral small vessel disease (white matter lesions; Fazekas score ≥ 2) on MRI
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Medical history of diabetes mellitus
• Experienced myocardial infarction within the past 12 months
• Medical history of stroke in the past 6 months or large (sub) cortical cerebral infarction on MRI
• Medical history of end stage heart failure (NYHA III-IV)
• Stage 4-5 kidney failure
• Diagnosed with dementia
• Life expectancy less than 1 year
• Unable to obtain an optimal window for TCD measurements during first visit at the outward patient clinic
• Significant stenosis (>70%) of the left of right common carotid artery
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6474 |
| NTR-old | NTR6661 |
| Ander register | METC VUmc : 2017.099 |