We would like to investigate whether intestinal choline and carnitine metabolism by microbiota is a transmissible trait using fecal transplantation from either allogenic (lean vegetarian/vegan) or autologous (own) donors on a) postprandial choline…
ID
Bron
Verkorte titel
Aandoening
subjects with metabolic syndrome; intestinal choline and carnitine metabolism; TMAO; vascular inflammation
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
changes in postprandial choline and carnitine metabolism (d6-labeled choline and d3-labeled carnitine) and fecal gutmicrobiota composition between baseline and 2 weeks after vegetarian/vegan microbial transplantation
Achtergrond van het onderzoek
in this trial we would like to investigate the causality of intestinal microbiota in carnitine/choline metabolism and TMAO levels in relation to PETCT based inflammation in male subjects with metabolic syndrome treated either with lean vegetarian/vegan donor (allogenic) or own feces (autologous)
Doel van het onderzoek
We would like to investigate whether intestinal choline and carnitine metabolism by microbiota is a transmissible trait using fecal transplantation from either allogenic (lean vegetarian/vegan) or autologous (own) donors on a) postprandial choline (oral d6-labeled choline) and carnitine (oral d3-labeled carnitine) metabolism, b) vascular inflammation (PETCT) and c) subcutaneous adipose tissue inflammation in male obese subjects with metabolic syndrome.
Onderzoeksopzet
0 and 2 weeks
Onderzoeksproduct en/of interventie
lean vegetarian/vegan donor feces
Publiek
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Wetenschappelijk
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
patients: treatment naive male obese patients with metabolic syndrome; 21 to 69 years-old; body mass index (BMI) 30 to 43 kg/m2
fecal donors: male healthy, lean, vegetarian/vegan ( 21 to 69 years old, BMI between 20 and 25 kg/m2, no medication use)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
patients: Supplement use (including vitamin/choline/carnitine supplements, energy drinks and carnitine-enriched soymilk) is not allowed. Other exclusion criteria are a medical history of a cardiovascular event (myocardial infarction/stroke), cholecystectomy, use of medication including antacids and oral antibiotics in the past three months and immunodeficiency.
donors: Presence of fecal bacterial pathogens and viruses; history of a cardiovascular event (myocardial infarction/stroke), cholecystectomy, use of medication including antacids and oral antibiotics in the past three months; Supplement use (including vitamin/choline/carnitine supplements, energy drinks and carnitine-enriched soymilk)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4188 |
| NTR-old | NTR4338 |
| CCMO | NL41928.018.12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON39717 |