Near-infrared fluorescent imaging can accurately detect neuroendocrine tumors non-invasively during surgical procedures.
ID
Bron
Verkorte titel
Aandoening
Neuroendocrine tumors
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Primary outcome parameter is the number of identified neuroendocrine tumors.
Achtergrond van het onderzoek
Intraoperative identification of neuroendocrine tumors can be very challeging. Complete resection of the tumor is essential for curation. To reduce the number of patients with positive resection margins, near-infrared fluorescence imaging can be very usefull.
The aim of this study is test feasibility for intraoperative detection of neuroendocrine tumors using methylene blue and NIR fluorescence.
Doel van het onderzoek
Near-infrared fluorescent imaging can accurately detect neuroendocrine tumors non-invasively during surgical procedures.
Onderzoeksopzet
The primary and secondary outcomes will be assessed during surgery and pathological assessment.
Onderzoeksproduct en/of interventie
Standard surgical procedure will be performed. During surgery, the near-infrared dye Methylene blue (MB) will be injected and the neuroendocrine tumor will be visualized non-invasively using our experimental camerasystem.
Publiek
Department of Surgical Oncology,
P.O. Box 9600
C.J.H. Velde, van de
Leiden 2300 RC
The Netherlands
+31 (0)71 5262309
c.j.h.van_de_velde@lumc.nl
Wetenschappelijk
Department of Surgical Oncology,
P.O. Box 9600
C.J.H. Velde, van de
Leiden 2300 RC
The Netherlands
+31 (0)71 5262309
c.j.h.van_de_velde@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients diagnosed with neuroendocrine tumors eligible to undergo a curative resection;
2. Age between 18 and 80 years old.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Patients using SSRI's, SNRI's of TCA's;
2. Allergy to methyleen blue, history of severe renal impairment or G6PD-deficiency;
3. Patient pregnant or lactating.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3558 |
| NTR-old | NTR3714 |
| Ander register | METC LUMC : P10.001 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |