That minimal invasive laparoscopic surgery and/or multimodal patient care (fast track) can prevent post operative ileus and/or improve post-surgical gastrointestinal motility compared to open surgery and/or conventional patient care.
ID
Bron
Verkorte titel
Aandoening
Colorectal cancer
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Gastrointestinal transit.
Achtergrond van het onderzoek
Postoperative ileus (POI) is defined as delayed recovery of gastrointestinal motor function (motility) and is still considered an unavoidable consequence of abdominal surgery.
Aim:
To evaluate to what extend minimal invasive laparoscopic surgery and/or multimodal patient care (fast track) can prevent POI and/or improve post-surgical gastrointestinal motility if compared to open surgery and/or conventional patient care.
Patients and methods:
The current study protocol is an addendum on the LAFA protocol.
At the start and at the end of the surgical procedure peritoneal lavage fluid and blood samples are collected. Cytokine levels in these samples will be determent and cells will be isolated.
24 hours postoperative a labeled test-meal will be administered orally. Abdominal scans will be made 2, 24 and 48 hours after intake of the test-meal.
Doel van het onderzoek
That minimal invasive laparoscopic surgery and/or multimodal patient care (fast track) can prevent post operative ileus and/or improve post-surgical gastrointestinal motility compared to open surgery and/or conventional patient care.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Laparoscopic surgery and fast track perioperative care.
Publiek
P.O. Box 22660
J. Wind
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5663170
J.Wind@amc.uva.nl
Wetenschappelijk
P.O. Box 22660
J. Wind
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5663170
J.Wind@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age between 40 and 80 years;
2. Colorectal cancer including colon and rectosigmoid cancers;
3. Informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Prior midline laparotomy;
2. ASA IV;
3. Laparoscopic surgeon not available;
4. Prior upper and/or lower midline laparotomy;
5. Emergency colectomy;
6. Contraindications for epidural (coagulation disorders);
7. Planned stoma.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL238 |
NTR-old | NTR276 |
Ander register | : N/A |
ISRCTN | ISRCTN26698501 |