The association between the gut microbiome/virome, T-cell exhaustion and immuno-tolerance in T1D constitutes an important knowledge gap and may serve as a therapeutic target in T1D, that will be adressed in this cohort study.
ID
Bron
Verkorte titel
Aandoening
type 1 diabetes
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
associations between residual beta cell function (2-hour post-meal urinary C-peptide / creatinine ratio), gut microbiome composition and circulating T-cell immune cell function
Achtergrond van het onderzoek
It has become apparent that most individuals with type 1 diabetes mellitus (T1D) have some remaining beta cell function. Individuals with T1D and a preserved beta cell mass have a lower risk of hypoglycaemia and diabetic complications. The factors regulating residual beta cell function are unknown. A likely mechanism leading to a large beta cell reserve is regulation of immunological tone by the gut microbiome. Therefore, we will investigate whether residual beta cell mass is associated with gut micro-biome composition and circulating immune cell counts in individuals with T1D.
Doel van het onderzoek
The association between the gut microbiome/virome, T-cell exhaustion and immuno-tolerance in T1D constitutes an important knowledge gap and may serve as a therapeutic target in T1D, that will be adressed in this cohort study.
Onderzoeksopzet
1 day (only one study visit)
Onderzoeksproduct en/of interventie
none
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
All individuals with T1D visiting the outpatient clinic of recruiting centres in the greater Amsterdam region
>18 years old.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Active infection at the time of inclusion (not to influence immune-cell function)
• Antibiotic or proton-pump inhibitor use last 3 months (not to influence
microbiome)
• Unwillingness to donate feces, urine and/or blood
• Inability to provide informed consent based on cognitive function, language
barrier or other reasons
• Absence of large bowel (ie colostomy).
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8931 |
| Ander register | METC AMC : 2020-105 |