The presence of a broadly reactive anti-donor specific memory B cell compartment is a risk factor for an accelerated memory response after transplantation.
ID
Bron
Verkorte titel
Aandoening
kidney transplant recipients
niertransplantatie patiënten
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main parameter to be assessed in the current study is the frequency of donor-specific memory B cells as determined by a novel ELISPOT based technique. Furthermore, donor-specific antibody levels will be determined by CDC and Luminex techniques.
Doel van het onderzoek
The presence of a broadly reactive anti-donor specific memory B cell compartment is a risk factor for an accelerated memory response after transplantation.
Onderzoeksopzet
Peripheral blood (30 ml per time point) will be drawn by venapuncture at 3 time points (pre-transplant, at 3 and 6 months post-transplantation). Clinical follow-up will be performed up to 1 year after transplantation. In case of a living donor transplant, 30 ml of peripheral blood will be drawn from the kidney donor once before the explantation.
Onderzoeksproduct en/of interventie
N/A
Publiek
Leiden University Medical Center
Albinusdreef 2
Leiden 2333 ZA
The Netherlands
s.heidt@lumc.nl
Wetenschappelijk
Leiden University Medical Center
Albinusdreef 2
Leiden 2333 ZA
The Netherlands
s.heidt@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients who will undergo a kidney retransplant and, if applicable, their living kidney donor
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Hepatitis C or HIV seropositive individuals
Opzet
Deelname
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| Register | ID |
|---|---|
| NTR-new | NL4553 |
| NTR-old | NTR4695 |
| Ander register | NL42616.058.12 : P13.025 |