To investigate the role and mechanisms of leukocytes in allogeneic erythrocyte concentrates on postoperative complications, as MODS, infections and death.
ID
Bron
Verkorte titel
Aandoening
Cardiac valve surgery +/- CABG.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
90-days mortality and causes of deaths.
Achtergrond van het onderzoek
The primary outcome and some secondary outcomes are published. The analysis of blood samples are still continuing and the long-term analysis is still ungoing.
Doel van het onderzoek
To investigate the role and mechanisms of leukocytes in allogeneic erythrocyte concentrates on postoperative complications, as MODS, infections and death.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Randomization to receive buffy-coat-depleted (PC) or leukocyte-depleted transfusions when necessary. Pre-operative, at arrival at ICU and day 1 postoperatively at ICU blood samples were obtained.
Publiek
Plesmanlaan 1a
Y.M. Bilgin
Plesmanlaan 1a
Leiden 2333 BZ
The Netherlands
+31 (0)71 5685053
bilginyavuz@hotmail.com
Wetenschappelijk
Plesmanlaan 1a
Y.M. Bilgin
Plesmanlaan 1a
Leiden 2333 BZ
The Netherlands
+31 (0)71 5685053
bilginyavuz@hotmail.com
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients undergoing valve surgery (+/- CABG).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients under 18 years of age, patients with medical indications for leucocyte-depleted erythrocytes and who received blood transfusions within previous 3 months.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL298 |
| NTR-old | NTR336 |
| Ander register | : N/A |
| ISRCTN | ISRCTN68522192 |
Samenvatting resultaten
Transfus Med. 2005 Jun;15(3):209-17.