We hypothesize that a single night of short sleep duration (4 hours), compared to normal sleep duration (8 hours) reduces metabolic flexibility, increases insulin resistance and thereby reduces HPA-reactivity. Furthermore, we hypothesize that a…
ID
Bron
Aandoening
Sleep; metabolism; mood; stress
Slaap; metabolisme; stemming; stress
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Metabolic flexibility; measured as change in RQ and lipid levels after a standard meal<br>
- Stress responsiveness; measured as change in stress hormones, heart rate and blood pressure after a mild physical stressor
Achtergrond van het onderzoek
In modern daily life, incidental short sleep duration has become a common feature. Chronic short sleep duration is associated with a many adverse health effects, including metabolic disturbances such as obesity, type 2 diabetes and cardiovascular diseases, as well as disturbances in the stress system, negative mood and tissue ageing. These associations may be explained by metabolic disturbances caused by repeated incidental short sleep duration.
This study aims to investigate the effects of a single night of short sleep on metabolism, mood and stress responsiveness. To this end, we will include healthy participants in a cross-over intervention trial and subjects participants to both short and normal sleep.
Doel van het onderzoek
We hypothesize that a single night of short sleep duration (4 hours), compared to normal sleep duration (8 hours) reduces metabolic flexibility, increases insulin resistance and thereby reduces HPA-reactivity. Furthermore, we hypothesize that a single night of short sleep will negatively affect mood and tissue ageing due to dysregulation of HPA-axis. Since BMI is correlated with metabolic inflexibility and insulin resistance, we hypothesize that individuals with a higher BMI will show a more detrimental effect of short sleep on metabolism, HPA-axis reactivity and downstream effects on mood and tissue ageing, than individuals with a lower BMI.
Onderzoeksopzet
Outcome parameters will be measured on the day immediately following the sleep intervention.
Onderzoeksproduct en/of interventie
One night of short sleep (4h) will be compared to one night of normal sleep (8h).
Publiek
Rosa van den Berg
Dept. of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
P.O.Box 9600
Leiden 2300 RC
The Netherlands
0031 (0) 71- 5268172
R.van_den_Berg.ENDO@lumc.nl
Wetenschappelijk
Rosa van den Berg
Dept. of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
P.O.Box 9600
Leiden 2300 RC
The Netherlands
0031 (0) 71- 5268172
R.van_den_Berg.ENDO@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Informed consent
- Male Caucasian
- Age between 18 and 55 years
- BMI between 20 and 35 kg/m2
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Active endocrine disease (e.g. diabetes mellitus type 1 and type 2, thyroid disease, any signs of Cushing’s syndrome, adrenal disease and lipid-associated disorders such as FH)
- Fasting glucose >7.0 mmol/L
- Severe chronic disease (e.g. chronic liver or kidney disease)
- Severe insomnia, sleep disorders or exceptional habitual sleep duration (<6 or >10 h).
- Medication use including the following: lipid lowering drugs, glucocorticoids, sleep medication, hormone replacement, glucose lowering drugs, insulin therapy, antidepressants and psychotropic drugs (last 6 weeks)), anti-coagulants
- Recent time zone travel (last 6 weeks)
- Shift work (last 6 weeks)
- Severe alcohol use (>21 units/week)
- Psychiatric disease
- Drug abuse
- Recent participation to another nutritional or biomedical trial (last 6 weeks)
- Medication use which may interfere with study measurements, as judged by the responsible physician
- Reported weight loss or weight gain (10%) in the last six months prior to the pre-study screening
- Clinically relevant abnormalities in clinical chemistry at screening (to be judged by the study physician)
- Reported use of any nicotine containing products in the six months preceding the study and during the study itself;
- Extreme strenuous exercise during last 3 months, as judged by responsible physician
- Excessive sunbathing during last 3 months, as judged by responsible physician.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5680 |
| NTR-old | NTR5824 |
| Ander register | ABR dossiernummer NL55111.058.15 : Protocol-ID P15.353 |
Samenvatting resultaten
Donga,E., van,D.M., van Dijk,J.G., Biermasz,N.R., Lammers,G.J., van,K.K., Hoogma,R.P., Corssmit,E.P., and Romijn,J.A. (2010b). Partial sleep restriction decreases insulin sensitivity in type 1 diabetes. Diabetes Care 33, 1573-1577.