Efficacy of Multi-Gyn LiquiGel for the relief of complaints related to vaginal dryness in post-menopausal women

With the reduction in estrogen levels that occurs during menopause, physiologic and structural changes occur within the vulvovaginal mucosa that lead to a condition commonly called atrophic vaginitis. In this condition, the cells of the vaginal wall are less developed than in the fertile age, and is often associated with reduced production of vaginal secretions.

Although mild genital changes occur in most women, 10-47% of postmenopausal women will develop one or more debilitating symptoms that include vulvovaginal dryness, dyspareunia, itching, irritation/burning and intercourse bleeding.

Vaginal moisturizers can provide relief by supplementing the vaginal fluid to help maintain natural secretions, correct the vaginal pH and improves comfort during intercourse. The aim of the current study is to investigate the efficacy of Multi-Gyn LiquiGel to relief vaginal complaints related to post-menopausal atrophy.

Vaginal atrophy in post-menopausal women results in various vaginal complaints, including dryness. Multi-Gyn LiquiGel is a moisturizing gel with osmo-protectant ingredients. We hypothesize that LiquiGel relieves signs and symptoms of vaginal atrophy and improves atrophy scores of vaginal epithelial cells.

Women will undergo a physical vaginal examination and smears for cytological analysis will be taken after 0, 1, 4 and 12 weeks.

During the first week of treatment, 2 ml of the assigned study product will be applied intravaginally 2 times per day. In the next 11 weeks, 2 ml of the assigned study product will be applied 3 times/week.