The ADMA-level in hypertensive subjects will be reversely related to the basal blood flow and the endothelial NO-availability in the forearm. Pre-treatment with an angiotensin-II- receptorblocker and/or a statin will decrease the ADMA-levels via…
ID
Bron
Verkorte titel
Aandoening
1. Hypertension (hypertensie);
2. high blood pressure (hoge bloeddruk);
3. mild renal insufficiency (milde nierfunctiestoornissen).
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Forearm blood flow (FBF).
Achtergrond van het onderzoek
In this study the relationship between the systemic NO-mediated endothelium-dependant vasodilatation, measured as forearm blood flow and venous ADMA-level is studied, in hypertensive as well as healthy subjects. In the hypertensive subjects it also will be examined to what extend the forearm blood flow (FBF) can be influenced by treatment with an angiotensin-II- receptorblocker (eprosartan) and/or a statin (rosuvastatin).
Doel van het onderzoek
The ADMA-level in hypertensive subjects will be reversely related to the basal blood flow and the endothelial NO-availability in the forearm. Pre-treatment with an angiotensin-II- receptorblocker and/or a statin will decrease the ADMA-levels via increased clearance of ADMA and, consequently, will ‘normalise’ the forearm blood flow and NO-availability.
Onderzoeksopzet
Baseline forearm blood flow measurement (without medication) at t=0. Second forearm blood flow measurement 3 weeks later.
Onderzoeksproduct en/of interventie
The patients will be treated with eprosartan 600 mg and/or rosuvastatin 20 mg during a three-weeks interval.
Publiek
Department of Internal Medicine
A.A. Kroon
P. Debyelaan 25
Maastricht 6229 HX
The Netherlands
+31 (0)43 3875100
akr@sint.azm.nl
Wetenschappelijk
Department of Internal Medicine
A.A. Kroon
P. Debyelaan 25
Maastricht 6229 HX
The Netherlands
+31 (0)43 3875100
akr@sint.azm.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Hypertension (without medication blood pressure >140/90 mmHg and <180/110 mmHg);
2. creatinine clearance 60-90 ml/min;
3. microalbuminuria (30-300 mg albumin/24 hours);
4. age 18-75 years;
5. BMI between 18 and 30 kg/m2.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Diabetes mellitus;
2. contra-indication for use of an angiontensin-II-receptorblocker or statin.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1071 |
| NTR-old | NTR1104 |
| Ander register | : 2605 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |