This study tests the hypothesis that age has an effect on prefrontal brain activity, measured by fNIRS and EEG, during a cognitive paradigm assessing proactive response inhibition and working memory. The results of the fNIRS-EEG study will be…
ID
Bron
Verkorte titel
Aandoening
aging - veroudering
working memory - werkgeheugen
response inhibition - respose inhibitie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin concentration changes (ìmol/L), measured during baseline and the performance of the cognitive paradigm
Doel van het onderzoek
This study tests the hypothesis that age has an effect on prefrontal brain activity, measured by fNIRS and EEG, during a cognitive paradigm assessing proactive response inhibition and working memory.
The results of the fNIRS-EEG study will be compared with the results of a fMRI study with the same cognitive paradigm
Onderzoeksopzet
1
Onderzoeksproduct en/of interventie
We will measure cerebral blood flow (with fNIRS) at the prefrontal cortex, and electrical activity (with EEG) at the scalp in young and elderly healthy subjects, during the performance of a working memory task and a response inhibition task. The study has a cross-sectional design and no intervention is applied.
Publiek
P.O. Box 8129
Ondine Rest, van de
Wageningen 6700 EV
The Netherlands
+31 (0)317 485867
Ondine.vandeRest@wur.nl
Wetenschappelijk
P.O. Box 8129
Ondine Rest, van de
Wageningen 6700 EV
The Netherlands
+31 (0)317 485867
Ondine.vandeRest@wur.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Males and females aged 18-35 years (young adults group)
- Males and females aged 60-75 years (older adults group)
- Right-handed
- Dutch speaking
- Good health (see exclusion criteria)
- Non-smoking (max. 1 cigarette per day)
- Normal or corrected-to-normal vision
- Signed informed consent available
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Mini-Mental State Examination (MMSE) score ¡Ü 26 (older subjects group)
- Estimated IQ < 85 (based on Nederlandse Leestest voor Volwassenen [NLV]-score)
- Colour blindness
- Current or past psychiatric disorder, such as psychosis or major depression.
- Current or past neurological disorder, such as severe cerebral vascular disease (e.g. cortical stroke, subarachnoid hemorrhage), Parkinson¡¯s disease, epilepsy, traumatic brain injury, central nervous system infection, brain tumor, and alcoholic encephalopathy
- Current or past severe systemic disease such as coronary artery disease, myocardial infarction <6 months, heart failure (unstable), chronic obstructive pulmonary disease (unstable)
- Type 1 or type 2 diabetes mellitus
- Previous head surgery
- Excessive alcohol use (on average >3 consumptions per day)
- Recurrent migraine
- General medical conditions, such as repetitive strain injury (RSI), which may confound the results of the study, as judged by the investigator
- Use of psychopharmacological drugs (anxiolytics, antidepressants, antipsychotic drug, long-acting benzodiazepines etc.)
- Use of cardiovascular drugs (including antihypertensives)
- Current participation in another study or previous participation in the fMRI study of the Donders Institute of Brain, Cognition and Behaviour, Nijmegen.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4137 |
| NTR-old | NTR4641 |
| Ander register | CMO Regio Arnhem-Nijmegen : 2014/029 |