To validate the hypothesis by Sampson on retrograde menstruation by using modern imaging modalities.
ID
Bron
Verkorte titel
Aandoening
Endometriosis, Retrograde menstruation, theory of Sampson.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The difference in the amount of blood-stained peritoneal fluid measured by TVUS and MRI in women with endometriosis versus healthy controls.
Achtergrond van het onderzoek
Endometriosis is defined as the presence of endometrial- like tissue (which is in normal circumstances only inside the uterus) within the pelvis and other extra-uterine sites. It is a common estrogen dependant disease which is thought to affect up to 10% of women of reproductive age. This can rise up to 35-50% in women presenting with pelvic pain and infertility or both. The etiology remains unclear. Sampson described the theory of menstruation in 1927. This theory describes the backflow of menstrual fluid from the uterine cavity through the tubes to the peritoneal cavity. In this study we will test this theory with modern imaging techniques (TVUS and MRI).
Doel van het onderzoek
To validate the hypothesis by Sampson on retrograde menstruation by using modern imaging modalities.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
On Cycleday 2 and Cycleday 20 a gynaecological investigation, a transvaginal ultrasound and MRI will be performed. Also a bloodsample (serum Ca 125) will be collected.
In case of a cystectomy also a pippelle from the endometrium will be taken.
Publiek
A.B. Luchinger
Amsterdam 1081 HV
The Netherlands
+31 (0)20 4445278
abluchinger@vumc.nl
Wetenschappelijk
A.B. Luchinger
Amsterdam 1081 HV
The Netherlands
+31 (0)20 4445278
abluchinger@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Female<40 years;
2. Subfertility;
3. Patent tubes (at HSG or laparoscopy with chromopertubation);
4. Regular menstrual cycle (28 days +/- 3 days);
5. Cases: presence of endometriosis confirmed by laparoscopy;
6. Controls: no presence of endometriosis confirmed by laparoscopy;
7. Signed informed consent;
8. Negative pregnancy test.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Female age>40 years;
2. Hormone therapy;
3. Contra indications for MR imaging (e.g.pacemaker, claustrophobia);
4. Positive pregnancy test;
5. Laparoscopy > 1 year ago;
6. Evidence of tubal occlusion seen at HSG or laparoscopy;
7. Presence of any malignancy;
8. Frozen pelvis.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2106 |
| NTR-old | NTR2223 |
| Ander register | METc VUmc : 2009/329 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |