Administration of a lipid emulsion consisting of long-chain triglycerides (LCT-trial) in non-trained individuals, will induce insulin resistance due to increased DAG accumulation and subsequent activation of the PKC pathway in skeletal muscle.…
ID
Bron
Verkorte titel
Aandoening
mitochondrial function, insulin resistance
mitochondrieel functioneren, insuline resistentie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Insulin sensitivity (hyperinsulinemic-euglycemic clamp) and mitochondrial function.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Administration of a lipid emulsion consisting of long-chain triglycerides (LCT-trial) in non-trained individuals, will induce insulin resistance due to increased DAG accumulation and subsequent activation of the PKC pathway in skeletal muscle. Infusion of long-chain triglycerides (LCT-trial) in endurance-trained subjects will result in no -or less pronounced- insulin resistance, because of a better capacity to mobilize and/or oxidize fatty acids. In case of infusion of medium-chiain triglycerides (MCT-trial), the induction of insulin resistance will be absent for both, trained- and non-trained subjects.
Onderzoeksopzet
The clamps will be separated by at least 1 week in each subject.
Onderzoeksproduct en/of interventie
All subjects will undergo three hyperinsulinemic euglycemic clamps, in a random order, with simultaneous infusion of either glycerol (control trial), LCT or MCT/LCT.
Publiek
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl
Wetenschappelijk
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Male sex;
2. Age 18-35 years;
3. BMI < 25 kg/m2;
4. Stable dietary habits.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Family history of diabetes;
2. Medication use.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1888 |
| NTR-old | NTR2002 |
| Ander register | METC Maastricht University Medical Center : 06-3-049 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |