We think that CEUS has an additional value in identifying the (micro)vasculature of uterine fibroids compared to 3D power Doppler ultrasound. We hypothesize that in the future CEUS could be useful for the prediction of fibroid responsiveness for…
ID
Bron
Aandoening
fibroids, contrast enhanced sonography, ultrasound
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- To test the feasibility of CEUS in visualizing uterine leiomyomas and their vascularization. <br>
- To observe the enhancement pattern and time-intensity curve obtained from CEUS.
Achtergrond van het onderzoek
With Contrast Enhanced UltraSound (CEUS) the microvascularisation of uterine leiomyomas can be visualized with the potential to improve ultrasound imaging for uterine leiomyoma detection. This can be useful for treatment choice and therapeutic monitoring of uterine leiomyomas. The past years numerous studies have been preformed with CEUS, but only a few small series were reported on using CEUS in the assessment of uterine leiomyomas. To our knowledge there are no studies that compare the diagnostic value of CEUS in identifying uterine leiomyomas compared to 3D power Doppler, with MRI as a reference standard, which is the aim of this current study.
Multicenter: VUmc and AMC
Doel van het onderzoek
We think that CEUS has an additional value in identifying the (micro)vasculature of uterine fibroids compared to 3D power Doppler ultrasound. We hypothesize that in the future CEUS could be useful for the prediction of fibroid responsiveness for specific therapies and for the monitoring of uterine leiomyomas. We will use dynamicMRI as a reference standard.
Onderzoeksopzet
Patients will receive one dynamic MRI and at one timepoint a contrast sonography of the uterus.
Onderzoeksproduct en/of interventie
Patients will undergo a 3D power Doppler, CEUS and a MRI-scan.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Older than 18 years of age; Suspected uterine leiomyomas; scheduled for dynamic MRI
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Postmenopausal woman
– Women with an known allergy to SonoVue or any of its components
- Woman with an history of any clinically unstable cardiac condition including class III/IV cardiac failure or right to left shunts
- Woman who have had a severe cardiac rhythm disorders within the last 7 days
- Woman with severe pulmonary hypertension or systemic hypertension treated or not treated or women with respiratory distress syndrome
– Contra-indications for dynamic MRI
– Pregnant and lactating women.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4266 |
| NTR-old | NTR4402 |
| Ander register | METC : 2014_087 |