To prospectively assess the efficacy, feasibility and safety of a systemised endoscopic surveillance protocol in large multicentre HPS cohort.
ID
Bron
Verkorte titel
Aandoening
hyperplastic polyposis CRC serrated adenoma HPSB colorectal carcinoma HPS
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To prospectively assess the efficacy, feasibility and safety of a systemised endoscopic surveillance protocol in large multicentre HPS cohort.
Achtergrond van het onderzoek
Hyperplastic polyposis syndrome (HPS) is characterized by the presence of multiple colorectal serrated polyps and is associated with an increased colorectal cancer (CRC) risk. The prevalance of HPS is estimated to be 1:3000 which makes HPS more common than other polyposis syndromes such as FAP. Due to the risk of malignant polyp transformation, HPS patients undergo endscopic surveillance with removal of polyps or a surgical colonic resection. However, no uniform and adequately substantiated endoscopic management protcol exists regarding polyp removal and surveillance intervals.
Aim:
To prospectively assess the efficacy, feasibility and safety of a systemised endoscopic surveillance protocol in large multicentre HPS cohort.
Doel van het onderzoek
To prospectively assess the efficacy, feasibility and safety of a systemised endoscopic surveillance protocol in large multicentre HPS cohort.
Onderzoeksopzet
3 years.
Onderzoeksproduct en/of interventie
Data are collected in prospective manner from patients during a routine annual endoscopies with removal of all polyps < 3 mm.
Publiek
Y. Hazewinkel
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662806
y.hazewinkel@amc.uva.nl
Wetenschappelijk
Y. Hazewinkel
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662806
y.hazewinkel@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
HPS patients defined as:
> 5 HPs/SSA proximal to the sigmoid, of which 2 > 10 mm in diameter, or more than 20 HPs/SSAs distributed throughout the colon.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Carriers of a germline mutation in the MutYH or APC gene and individuals who have undergone a total colonic resection.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2629 |
| NTR-old | NTR2757 |
| Ander register | METC AMC : 10.17.2005 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |