This study tests the hypothesis that reward mechanisms in PD are dysfunctional and that this dysfunction is correlated with an increased severity of symptoms of apathy, depression and HDD.
ID
Bron
Verkorte titel
Aandoening
Parkinson's disease
(NLD: De ziekte van Parkinson).
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Main study parameters are the performance on neuropsychiatric and neuropsychological tests for both groups, including assessments of cognitive status, mood, apathy, and an observation of spontaneous self-reward behaviour.
Achtergrond van het onderzoek
In Parkinson's disease (PD) degeneration of dopaminergic cells in the mesocorticolimbic pathway is implied int he pathophysiology of several non-motor symptoms related to motivation and reward, such as apathy, depression, and hedonistic homeostatic dysregulation (HDD), a syndrome that is characterized by obsessive behaviour, addiction, compusive seeking of dopamine replacement therapy (DRT), and hypersexuality. Apathy is reproted in 16 to 42 % of PD patients, while depression occurs in in 25 to 40 %. Both apathy and depression have a serious negative impact on everyday functioning, cognitive and motor performance and quality of life for both patient and partner or caretaker. HDD, although less prevalent (around 4% of patients), can also be severely disruptive. Insight in the pathophysiology of these syndromes may pave the way for rational treatments and improved outcomes.
Doel van het onderzoek
This study tests the hypothesis that reward mechanisms in PD are dysfunctional and that this dysfunction is correlated with an increased severity of symptoms of apathy, depression and HDD.
Onderzoeksopzet
These outcome measures will be rated on three different testing days, before and after the administration of methylphenidate, pramipexole or placebo.
Onderzoeksproduct en/of interventie
All subjects receive a 10 mg methylphenidate challenge, a 500 ìg pramipexole challenge and a placebo condition.
Publiek
Maastricht University, DOT 12
Postbus 616
R.L. Drijgers
Maastricht 6200 MD
The Netherlands
043-3881839
rosa.drijgers@np.unimaa
Wetenschappelijk
Maastricht University, DOT 12
Postbus 616
R.L. Drijgers
Maastricht 6200 MD
The Netherlands
043-3881839
rosa.drijgers@np.unimaa
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Idopathic Parkinson's disease;
2. Informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Other concurrent neurological diseases than PD;
2. Concurrent psychiatric disease;
3. Use of psychopharmacological medication;
4. Abuse of alcohol and drugs;
5. Cognitive deterioration as operationalized by a score of <23 on the MMSE;
6. Use of levodopa preparations of dopamine agonists.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1082 |
| NTR-old | NTR1115 |
| Ander register | : MEC 07-3-087 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |