Our hypothesis is that MRKH patients are exposed to high concentrations AMH in utero, coming from their male co-twin (possible vanished twin). This AMH-exchange is possible because of intrauterine blood exchange between two fetuses. This blood…
ID
Bron
Verkorte titel
Aandoening
MRKH syndrome
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcome is the difference in occurrence of microchimerism (with an extra male cell line) in MRKH patients vs. controls.
Achtergrond van het onderzoek
The aim of this study is to determine whether male microchimerism is present in patients with MRKH syndrome. This would be a result of intrauterine cell trafficking - and possible AMH transfer- from male to female co-twin.
Study design: Observational case control study.
In the course of this study we ask the subjects for one visit to the outpatient clinic or a home visit for blood sampling, collecting of a buccal smear and a short questionnaire.
Doel van het onderzoek
Our hypothesis is that MRKH patients are exposed to high concentrations AMH in utero, coming from their male co-twin (possible vanished twin). This AMH-exchange is possible because of intrauterine blood exchange between two fetuses. This blood exchange results in male (micro)chimerism in blood. Our aim is to study the presence of this male microchimerism in adult patients with MRKH.
Onderzoeksopzet
Only one visit is necessary for blood sampling, buccal smear sampling and filling in a questionnaire (about medical history, family history, intoxications, BMI, age)
Onderzoeksproduct en/of interventie
96 patients with MRKH will be included. The controlgroup exists of 96 healthy women, already sampled. No interventions. Blood samples will be analyzed for Y-chromosome-specific real-time quantitative polymerase chain reaction.
Publiek
Henrike Peters
Postbus 7057
Amsterdam 1007 MB
The Netherlands
0204440561
h.peters@vumc.nl
Wetenschappelijk
Henrike Peters
Postbus 7057
Amsterdam 1007 MB
The Netherlands
0204440561
h.peters@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Diagnosed with MRKH syndrome
- Age ≥ 18 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
none
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5806 |
| NTR-old | NTR5961 |
| Ander register | ABR-nummer van de CCMO : 57503 |