Aim: to compare narrow band imaging (NBI) and standard white light endoscopy (WLE) for the detection of neoplasia during colonoscopic surveillance of patients with longstanding ulcerative colitis (UC).
ID
Bron
Verkorte titel
Aandoening
longstanding UC
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Number of patients with detected neoplasia.
Achtergrond van het onderzoek
Patients with longstanding UC will undergo colonoscopic surveillance by both WLE and NBI with a time interval of at least 4 weeks between the procedures. Randomization determines the order of the two techniques. During both procedures targeted biopsies will be taken from suspicious lesions. Only during the second procedure additional random biopsies will be taken according to current clinical guidelines. All detected lesions will be inspected and imaged with NBI and the mucosal morphology and vascular pattern will be classified. The histopathological outcome of the biopsies will be used as the gold standard for diagnosis.
Doel van het onderzoek
Aim: to compare narrow band imaging (NBI) and standard white light endoscopy (WLE) for the detection of neoplasia during colonoscopic surveillance of patients with longstanding ulcerative colitis (UC).
Onderzoeksproduct en/of interventie
NBI-Colonoscopy and WLE-colonoscopy.
Publiek
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Wetenschappelijk
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Objective diagnosis of UC (histologically and/or endoscopically);
2. Extensive UC (proximal to splenic flexure);
3. Disease duration > 8 years;
4. Inactive disease (Truelove Witts Index<2);
5. Informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Age < 18 years;
2. Non correctable coagulopathy.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL839 |
| NTR-old | NTR853 |
| Ander register | : N/A |
| ISRCTN | ISRCTN56671833 |