Persistent cognitive complaints of part of the women who experienced severe preeclampsia 0.5-1.5 year ago can be objectified by neuropsychological as well as cerebral hemodynamic tests.
ID
Bron
Verkorte titel
Aandoening
cognition
cerebral blood flow regulation
preeclampsia
pulse wave velocity
cognitie
cerebrale bloedstroom regulatie
preeclampsie
polsgolfsnelheid
Ondersteuning
Eindhoven University of Technology
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Correlation between degree of disturbance of the cerebrovascular control system and cognitive function in former preeclamptic patients.
Achtergrond van het onderzoek
Although the regulation of cerebral blood flow is known to be altered during preeclampsia, little is known about the state of the control mechanisms after the experience of preeclampsia. Nevertheless, several studies report evidence for formerly preeclamptics having a higher risk to die from stroke and a shorter life expectancy. Furthermore, our previous study shows that neurovascular coupling is abnormal in a subgroup of formerly preeclamptics. The question raised now is whether abnormalities in local blood flow regulation of formerly preeclamptics are related to cognitive function and to the persistent cognitive complaints which are regularly reported.
A few studies show that cognitive function is disturbed after severe preeclampsia, but discuss that it is not known whether this effect is permanent or temporal and whether it is caused by organic damage. Our working hypothesis is that test-objectified cognitive function of formerly preeclamptics with or without subjective cognitive complaints is correlated with dynamic cerebrovascular control parameters measured by non-invasive techniques for recording cerebral autoregulation and neurovascular coupling. The major objective is to investigate whether cognitive complaints of formerly preeclamptics are caused by organic damage (measured by brain function) which may be used to predict an increased risk for future cerebrovascular complications such as stroke.
Doel van het onderzoek
Persistent cognitive complaints of part of the women who experienced severe preeclampsia 0.5-1.5 year ago can be objectified by neuropsychological as well as cerebral hemodynamic tests.
Onderzoeksopzet
Single measurements within time span of 0.5-1.5 years after experience of preeeclampsia.
Onderzoeksproduct en/of interventie
No interventions tested, but correlation between parameters (cerebral blood flow regulation and cognition) in a single patient group (former preeclamptics).
Cerebral blood flow is measured non-invasively using transcranial Doppler ultasonography.
Cognition is objectified by neuropsychological test scores.
Publiek
Dept. Clinical Neurophysiology
P. Debyelaan 25
E. Martens
Maastricht 6229 HX
The Netherlands
+31 (0)43-387 5270
esther.martens@mumc.nl
Wetenschappelijk
Dept. Clinical Neurophysiology
P. Debyelaan 25
E. Martens
Maastricht 6229 HX
The Netherlands
+31 (0)43-387 5270
esther.martens@mumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Women who have been diagnosed with severe (clinical admission indispensable) early (< 34 weeks) preeclampsia 0.5-1.5 years ago in their first pregnancy;
2. Age > 18 years;
3. Informed consent of the patient before participation into the study.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Neurological or cerebrovascular disorders in case history;
2. Kidney function disorder;
3. Use of statines;
4. Psychiatric case history or state (As I and II issues);
5. Use of anti-depression medicine;
6. Abuse of alcohol and/or drugs;
7. Smoking or refrained from smoking less than 2 years;
8. Diabetes.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1525 |
| NTR-old | NTR1596 |
| CCMO | NL25268.068.08 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |
| OMON | NL-OMON33668 |