Epidural administration of corticosteroids in early onset sciatica gives clinically relevant pain reduction and functional recovery.
ID
Bron
Aandoening
sciatica
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Roland Disability Questionaire
2. Visual Analogue Scale (VAS) for back pain
3. Visual Analogue Scale (VAS) for leg pain
4. Global Perceived effect
Achtergrond van het onderzoek
Sciatica is a common condition afflicting 5-8 /1000 in the general population.
During the first weeks after onset the focus is on adequate pain reduction by use of pain medication or epidural injections with steroids.
The best treatment strategy is not known. Should all patients be injected? Or a subgroup? Or should patients be treated with medication only. What's the effect of different interventions?
To answer this question we compare 3 treatment groups of patients with acute sciatica:
1. pain medication only
2. epidural injection of steroids and local aneshetic
3. epidural injections of local anesthetic only
These are followed during 6 months. Outcomes are measured and compared using various scales including the Roland Morris scale and VAS.
In addition the costs are measured in terms of absenteism from work and number of operations (secondary outcome measures)
Doel van het onderzoek
Epidural administration of corticosteroids in early onset sciatica gives clinically relevant pain reduction and functional recovery.
Onderzoeksopzet
0-3-6 weeks, 3-6 months
Onderzoeksproduct en/of interventie
three groups:
1. pain medication only
2. epidural injection of steroids and local aneshetic
3. epidural injections of local anesthetic only
Publiek
B. Meulen, ter
Amsterdam 1064 AE
The Netherlands
020-5108911 (*589)
bas.termeulen@slaz.nl
Wetenschappelijk
B. Meulen, ter
Amsterdam 1064 AE
The Netherlands
020-5108911 (*589)
bas.termeulen@slaz.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. 18- 65 years of age
2. < 8 weeks sciatica
3. herniated disk on MRI as the cause of sciatica
4. correlation between symptoms and MRI findings
5. VAS 40 or more despite pain medication
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. weakness graded MRC 3 or more
2. spine surgery at the same level
3. foraminal stenosis as the cause of symptoms
4. pregancy
5. severe comorbidity (e.g. cancer)
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4218 |
| NTR-old | NTR4457 |
| Ander register | Wet commissie VUMC : WC2013-062 |
Samenvatting resultaten
Ter Meulen BC, Van de Vegt M, Wouda E et al. NTVG. submitted