We hypothesis that collagen supplementation augments the benefits of jumping exercise for bone metabolism.
ID
Bron
Verkorte titel
Aandoening
N/A
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Blood parameters of bone turnover: Procollagen type I N propeptide (P1NP), carboxy-terminal crosslinking telopeptide of type I collagen (CTX-I)
Achtergrond van het onderzoek
Bone health is a critical factor for athletes as bones provide the levers for muscles to move the joints, and strong bones decrease the risk of bone fractures. Particularly cyclist can benefit from exercise and nutrition interventions to stimulate bone health, as this population is characterized by an impaired bone mineral density. Jumping exercise has been identified as a feasible and effective exercise intervention to stimulate collagen synthesis and increase BMD. However, there is considerable debate on the optimal volume and frequency of jumping exercise to maximize bone collagen synthesis. Furthermore, preliminary evidence suggests that collagen supplementation may also stimulate bone collagen synthesis. It is currently unknown whether collagen supplementation can augment the increase in bone collagen synthesis after jumping exercise. Hence, the main objective of the current study is to assess the effect of jumping exercise combined with collagen supplementation on bone turnover.
Doel van het onderzoek
We hypothesis that collagen supplementation augments the benefits of jumping exercise for bone metabolism.
Onderzoeksopzet
T = - 60, T = 0, T = 60, T = 120, T = 180, T = 240, T = 12h, T = 24h, T = 48h, T = 72h
Onderzoeksproduct en/of interventie
20 grams of collagen vs placebo and 5 minutes jumping exercise (once or twice daily)
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Male
• Age ≥18 and ≤35 years.
• BMI ≥18.5 and ≤27.5 kg/m2
• Willing to give blood samples
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Blood donation during the study period
• Currently smoking
• Severe allergy to nuts or intolerance to gluten, as supplements are being produced in factory that may have used nuts or gluten previously
• Consumption of >21 alcoholic beverages per week
• Use of illicit drugs
• Use of antibiotics in the past month
• Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, pulmonary disease, rheumatoid arthritis, orthopedic disorders, renal disease, liver disease, diabetes mellitus, inflammatory disease, cognitive impairment, and thyroid or parathyroid disease)
• Use of medications known to interfere with selected outcome measures (i.e. corticosteroids)
• (Chronic) injuries of the locomotor system that can interfere with the intervention.
• Current participation in another biomedical research study.
• Trained individuals (i.e. performing sport activities for more than 6 hours per week).
Opzet
Deelname
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