Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
ID
Bron
Aandoening
Type 2 diabetes, first-degree relatives of type 2 diabetic patients, insulin resistance, mitochondrial function
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Ex vivo mitochondrial function;<br>
2. In vivo mitochondrial function;<br>
3. Insulin sensitivity;<br>
4. Fat accumulation in muscle and heart;<br>
5. Indirect calorimetry.
Achtergrond van het onderzoek
We found a reduced basal ADP-stimulated and maximal mitohondrial respiratory capacity related to type 2 diabetes, which underlies the reduction in in vivo mitochondrial function, independent of mitochondrial content.
Doel van het onderzoek
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
Onderzoeksopzet
1. All metabolic measurements for one patient planned within one month.
2. All subjects underwent these metabolic measurements within 1.5 year.
Onderzoeksproduct en/of interventie
No intervention is performed.
Publiek
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl
Wetenschappelijk
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Well controlled type 2 diabetic patients;
2. Normoglycemic first-degree relatives with at least one first-line family member diagnosed with type 2 diabetes;
3. Normoglycemic control subjects;
4. BMI 27 - 30 kg/m2;
5. Age 50- 70 y.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Uncontrolled hypertension;
2. Active cardiovascular disease;
3. Liver disfunction;
4. Medication known to interfere with glucose metabolism (except for diabetic patients).
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1956 |
| NTR-old | NTR2074 |
| Ander register | METC Maastricht University Medical Center : 04-257 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
Samenvatting resultaten
<br>
Diabetes, VOL 57, November 2008.