Obesity is significantly associated with Atrial Fibrillation (AF), and, interestingly, if obese patients loose weight, AF dissapears in 50% of the cohort. On the other hand, adipose tissue (AT) functioning alters up weightchange. Therefore we…
ID
Bron
Verkorte titel
Aandoening
obesity, atrial fibrillation, adipose tissue, electrophysiology, metabolism, epicardial, paracardial, CT-scan
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
multiple outcomes to identify intra-individual changes of clinical and biochemical markers of AT characteristics upon drastic weightloss: <br>
- AT mass, distribution and ratios (EAT, PAT,VAT)<br>
- Circulating AT derived protein biomarkers, including: inflammatory markers<br>
- Circulating AT derived miRNAs <br>
- Locally AT derived protein biomarkers, extracted from VAT. Markers similar to those in circulation.<br>
- Locally AT derived miRNAs extracted from VAT. <br>
- Anthropometric measurements: height, weight, BMI, waist-circumference, hip-waist ratio.<br>
- Occurrence/absence of AF by an approved 7 days rhythm monitoring system. <br>
- International Physical Activity Questionnaire.
Achtergrond van het onderzoek
Obese patients experience more AF occurrences and recurrences compared to patients with a healthy BMI. Clinically, weight loss in obese patients with AF increases AF freedom in a dose-dependent manner, resulting in 50% absence of AF in patients losing >10% bodyweight. These results present a significant relationship between obesity and AF. However, details on the mechanisms underlying this relationship and on reversible pathological factors remain to be discovered.
Therefore, we designed a study in which obesity along with adipose tissue (AT) characteristics are studied upon drastic weight loss. Currently, how drastic weight loss reduces the pro-arrhythmic effect is unknown. AT characteristics before and after weight loss will be compared to AT characteristics from patients with and without AF, obtained from other studies. In this study we aim at investigating the alterations in cardiac AT mass, AT activity and anthropometrics that occur upon drastic weight loss, and at understanding how certain of these fat characteristics predispose to AF.
Doel van het onderzoek
Obesity is significantly associated with Atrial Fibrillation (AF), and, interestingly, if obese patients loose weight, AF dissapears in 50% of the cohort. On the other hand, adipose tissue (AT) functioning alters up weightchange. Therefore we hypothesize that AT functioning may be responsible for AF occurence.
Onderzoeksopzet
Pre-operative: CT scan, blood samples, holter, questioannaire, ECG
Operation: adipose tissue biopsies
Follow-up 6 months: holter, blood samples
Follow-up 12 months: CT scan, blood samples, holter, questioannaire, ECG
Onderzoeksproduct en/of interventie
1. Adipose tissue biopsies during bariatric surgery
2. Blood extraction pre operative and during follow-up
3. CT scan pre-operative and during follow-up
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Patient undergoing bariatric surgery (BMI above 35)
- Age above 40
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Taking 2 or more antihypertensiva
- Taking metformine for diabetes
- Heart diseases, for example myocardinfarct in past
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6989 |
| NTR-old | NTR7178 |
| Ander register | : Protocol ID: NL62056.018.17 |