Early and aggressive treatment of rheumatoid arthritis according to a strict treatment protocol results in a 70% remission of the disease within 2 years.
ID
Bron
Verkorte titel
Aandoening
Observational study.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Percentage of patients reaching DAS28<2.6.
Achtergrond van het onderzoek
Patients with recent onset RA are treated according to a tight step up medication scheme. Aim of treatment is to reach clinical remission of the disease as soon as possible, DAS 28 < 2.6. Introduction of anti-TNF medication is possible after the use of 2 DMARDs, according to the present Dutch regulations for the use of anti-TNF in clinical practice. If remission is reached with the use of anti-TNF and the disease stays in remission for 6 months, de anti-TNF dose will reduced and in the case of persisting remission be stopped. Radiographic damge and disease activity will be monitored regularly.
Doel van het onderzoek
Early and aggressive treatment of rheumatoid arthritis according to a strict treatment protocol results in a 70% remission of the disease within 2 years.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Tight control of disease activity by a strict treatment scheme and strictly defined decision moments for treatment changes.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. RA according to ACR1987 criteria;
2. diagnosis RA <3 months;
3. age >18;
4. no prior DMARD use;
5. DAS 28 > 3.2 and/or erosions.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Pregnancy/pregnancy wish.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL534 |
| NTR-old | NTR578 |
| Ander register | : N/A |
| ISRCTN | Incomplete info for ISRCTN |