We hypothesize that GABA could improve glucose tolerance and cardiovascular health after long-term supplementation
ID
Bron
Verkorte titel
Aandoening
Prediabetes, hypertension
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Postprandial glycaemic response during a 2 hour oral glucose tolerance test (OGTT)
Achtergrond van het onderzoek
In this double-blind parallel placebo controlled intervention study the effects of 3 times daily 500 mg gamma-aminobutyric acid (GABA) supplementation on glucose tolerance and cardiovascular health will be assessed in prediabetics.
Doel van het onderzoek
We hypothesize that GABA could improve glucose tolerance and cardiovascular health after long-term supplementation
Onderzoeksopzet
Parameters will be measured before and after the 12 week intervention period
Onderzoeksproduct en/of interventie
GABA supplement
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age between 50 and 70
BMI higher or equal to 27 kg/m2
Impaired fasting glucose (fasting glucose ≥ 5.6 and ≤ 6.9 mmol/L) or/and
Impaired glucose tolerance (glucose levels ≥ 7.8 and ≤ 11.1 mmol/L, 2-hours after an OGTT or/and glucose levels ≥8.6 mmol/L, 1-hour after an OGTT)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Has been diagnosed with diabetes
Having other conditions, like liver, pancreatic, cardiovascular, gastro-intestinal or endocrine diseases, that could influence the study results
Use of medications or supplements that could influence the study results
Sensitive to medical skin adhesives
More than 5kg weight change in the past 12 weeks
Excessive alcohol consumption (>21 glasses/week for men and >14 glasses/week for women on average)
Being an employee of Wageningen University, division Human Nutrition and Health
Currently a research subject in other research
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
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Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8796 |
| Ander register | METC-WU : 20/07 |