Reveal common mechanisms of compulsivity in OCD and GD and disorder specific characteristics of aspects that have been related to compulsivity: confidence in relation with preference for risky and ambiguous behavior, and (negative) outcome…
ID
Bron
Verkorte titel
Aandoening
obsessive-compulsive disorder, gambling disorder, repetitive behavior, magnetic resonance imaging (fMRI), compulsivity
obsessief-compulsieve stoornis, gokverslaving, controle verlies, kernspintomografie (fMRI), compulsiviteit
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
• Confidence and brain activation as measured with fMRI during the confidence task <br>
• Risk taking and ambiguous behaviour measure with a cognitive task and it’s correlation with confidence task.<br>
• Compulsive checking behavior as determined by the checking task
Achtergrond van het onderzoek
Investigating and comparing two disorders (i.e., obsessive compulsive disorder and disordered gambling) that
both have compulsive behaviors central to their pathology can elucidate common mechanisms of compulsivity in
psychiatry. In the present study we will investigate behavioral and neural mechanisms contributing to these
behaviors. We will explore three different aspects that have been related to compulsivity in previous studies: risky
and ambiguous behavior, confidence and (negative) outcome anticipation. Besides investigating the common
mechanisms of compulsivity in OCD and GD, we aim to elucidate disorder specific characteristics. To this end we
will use fMRI imaging and neurocognitive tasks to investigate the neurobiological correlates of these compulsive
behaviors in both gambling disorder and obsessivecompulsive
disorder.
Doel van het onderzoek
Reveal common mechanisms of compulsivity in OCD and GD and disorder specific characteristics of aspects that have been related to compulsivity: confidence in relation with preference for risky and ambiguous behavior, and (negative) outcome anticipation.
Onderzoeksopzet
At baseline (only one time point)
Onderzoeksproduct en/of interventie
Computer tasks
Publiek
Kapittelweg 29
Room 1.28
Nijmegen 6525 EN
The Netherlands
024-3668293
ruthvan.holst@radboudumc.nl
Wetenschappelijk
Kapittelweg 29
Room 1.28
Nijmegen 6525 EN
The Netherlands
024-3668293
ruthvan.holst@radboudumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
OCD group:
• DSM-5 diagnosis of OCD
• No other psychiatric disorder
• Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 20
• 18-65 years of age
• Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
GD group:
• DSM- 5 diagnosis for Gambling Disorder
• No other psychiatric disorders.
• Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
• 18-65 years of age
HC group:
• No current psychiatric diagnosis no history of OCD or GD.
• Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
• 18-65 years of age
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
All groups:
• Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI neurological disorders section
• IQ below 80
• insufficient command of the Dutch language
• MRI contraindications such as metal implants, claustrophobia, pregnancy
• recent (<2 weeks) use of psychotropic medication other than naltrexone (smoking and nicotine dependence is allowed in all groups).
• Endocrinological disorders or regular use of corticosteroids
• Current treatment with tricyclic antidepressant or antipsychotic medication
• Use of other psychotropic medication (apart from SSRI's), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
• Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
• Pregnancy
- Left-handedness
OCD group and HC group: scoring lower than 5 on SOGS (gambling severity) questionnaire; hence not suffering from gambling problems.
GD and HC group: scoring lower than 5 Y-BOCS; hence not suffering from OCD symptoms.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6171 |
| NTR-old | NTR6318 |
| Ander register | : 60297 |