To study the accuracy of the PISAPED perfusion scan criteria compared with CT scanning in patients aged < or = 50 years with suspected pulmonary embolism, a likley or high clinical probability and/or an abnormal D-dimer.
ID
Bron
Aandoening
Pulmonary embolism
longembolie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The diagnostic accuracy of the perfsuion scan criteria in comparison to CT scan.
Achtergrond van het onderzoek
CT scanning has become a standard test in the diagnostic workup of patients with suspected PE. However, young patients, especially women, likely have an increased risk of (breast) cancer due to radiation exposure with CT scanning. Perfusion scanning has a much lower radiation exposure burden. Therefore, in this study, the accuracy of the PISAPED criteria for the evaluation of perfusion scans for the diagnosis of PE is studied in comparison to CT scan. Patients aged < or = 50 years old with suspected PE who need CT scanning according to current diagnostic work up criteria (i.e. either a 'likely' or 'high' clinical probability or an abnormal D-dimer test) will undergo perfusion scintigraphy. Q scan and CT scan will be compared for the absence or presence of PE.
Doel van het onderzoek
To study the accuracy of the PISAPED perfusion scan criteria compared with CT scanning in patients aged < or = 50 years with suspected pulmonary embolism, a likley or high clinical probability and/or an abnormal D-dimer.
Onderzoeksopzet
Moment of diagnostic tests to rule out or confirm PE.
Onderzoeksproduct en/of interventie
Perfusion scintigraphy, chest X-ray and CT scan in patients with likely or high clinical probablity and/or an abnormal D-dimer with suspected pulmonary embolism.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
In- or outpatients aged < or = 50 years, with clinically suspected pulmonary embolism, who have a 'likely' (Wells score) or 'high' (revised Geneva score) clinical probability for pulmonary embolism and/or an abnormal D-dimer test and in hwom a cT scan will be made.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Age <18 years or > 50 years;
2. Pregnancy;
3 (Low molecular weight) heparin for longer than 48 hours prior to eligibility assessment;
4. Inability to perfom a perfusion scan withing 24 hrs after CT scan;
5. Participation in a therapeutic study for pulmonary embolism is not an exclusion criterion.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2087 |
| NTR-old | NTR2203 |
| Ander register | MEC LUMC - substudy : P07.266 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |