Veiligheid en effectiviteit van plaatsing van een biologisch afbreekbare stent in de slokdarm tijdens chemoradiatie therapie.

Most of the patients with locally advanced esophageal cancer receive chemoradiotherapy therapy prior to curative resection. This neoadjuvant therapy however often causes acute inflammation and oedema of the esophageal mucosa, which will increase difficulties in swallowing and may consequently further impair dysphagia and jeopardize the nutritional status of the patients. First data on a self-expanding plastic stent (fully covered) placed prior to chemoradiotherapy showed promising results with regard to improvement of dysphagia and safety. There were two main drawbacks; stent migration and the need for removal prior to surgery. We hypothesized that an uncovered biodegradable stent might refute these problems while the improvement of dysphagia remains. Therefore the objective of this prospective multicenter study is to investigate the safety and efficacy of a biodegradable uncovered expandable stent placement prior to neoadjuvant therapy of patients diagnosed with resectable esophageal carcinoma.

N/A

1. Baseline characteristics, at day of stent placement;

2. Painscore 1 and 2 days after stent placement;

3. Dysphagia score 1 week after stent placement and thereafter weekly until esophagectomy;

4. Weight changes: Dependent of conversation with dietician.

Placement of a biodegradable uncovered stent across across a malignant stricture in the esophagus.