We expect the protein synthesis rate in (avascular) femoral bone proximal to the fracture to be lower when compared to healthy femoral bone.
ID
Bron
Verkorte titel
Aandoening
Hip fracture
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Bone protein synthesis rates in the femoral shaft and femoral head tissue, expressed in FSR (%/h)
Achtergrond van het onderzoek
Skeletal muscle plasticity is defined by a dynamic balance between protein synthesis and protein breakdown rates. Recently, we have shown basal protein synthesis rates in various musculoskeletal tissues of the knee joint, including bone, cartilage, and tendon tissue. Interestingly, most of these tissues possess protein synthesis rates within the same range of skeletal muscle protein synthesis rates. However, it is not known whether the protein synthesis rates of bone tissue change after a traumatic event (i.e. bone fracture). In older adults, hip fractures are one of the most common fractures that require surgical intervention. After a hip fracture, the vitality of the femoral head is often reduced. It is not known whether osteonecrosis of the femoral head happens due to reduced protein synthesis or extensive breakdown. Therefore, this project will apply the stable isotope methodology to measure tissue-specific protein synthesis rates in fractured femoral bone.
Doel van het onderzoek
We expect the protein synthesis rate in (avascular) femoral bone proximal to the fracture to be lower when compared to healthy femoral bone.
Onderzoeksopzet
2.5h before start of surgery untill the end of the surgical procedures.
Onderzoeksproduct en/of interventie
None
Publiek
Floris Hendriks
0655522347
f.hendriks@maastrichtuniversity.nl
Wetenschappelijk
Floris Hendriks
0655522347
f.hendriks@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1) Written informed consent;
2) Recent (<24 h before admission to the hospital) femoral bone fracture requiring hip replacement surgery;
3) Admitted to MUMC+ to receive a femoral head-neck prosthesis or total hip replacement.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1) Physical restlessness due to delirium;
2) Rheumatoid arthritis;
3) Chemotherapy or radiotherapy;
4) (Multiple) Myeloma or other primary cancer tumor with possible bone metastasis;)5) Collagen disorders, e.g. Marfan and Ehler-Danlos;
6) Any other medical condition that may interfere with the safety of the subjects or the outcome parameters, in the investigators judgement;
7) Investigator’s uncertainty about the willingness or ability of the subject to comply with the protocol instructions;
8) Participation in any other studies involving investigational or marketed products concomitantly to entry into the study.
Opzet
Deelname
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