H0= Postprandial muscle protein synthesis rates do not differ between the 2 intervention groups (P>0.05) H1= Postprandial muscle protein synthesis rates differ between the 2 intervention groups (P
ID
Bron
Verkorte titel
Aandoening
Muscle protein metabolism
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Primary study parameters include myofibrillar protein synthesis rates, expressed as FSR (%/h), using muscle-protein bound L-[ring-13C6]-phenylalanine enrichments and muscle tissue-free and plasma L-[ring-13C6]-phenylalanine enrichments as precursor.
Doel van het onderzoek
H0= Postprandial muscle protein synthesis rates do not differ between the 2 intervention groups (P>0.05)
H1= Postprandial muscle protein synthesis rates differ between the 2 intervention groups (P<0.05)
Onderzoeksopzet
Blood and muscle samples will be collected at regular time intervals (bloodsamples every hour, 3 muscle biopsies during the 5h postprandial period).
Onderzoeksproduct en/of interventie
Subjects will either consume 40 g plantbased or animal protein (isonitrogenous amount) in the form of a ready-to-eat product (n = 12 per group).
Publiek
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Wetenschappelijk
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Males
• Aged between 18 - 35 years
• Healthy, recreationally active (max 3 days per week performing activities)
• BMI 18.5 – 27.5 kg/m2
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Females
• Diagnosed diabetes
• Wheat allergy
• Celiac disease
• Smoking
• Diagnosed metabolic or intestinal disorders
• A history of neuromuscular problems
• Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
• Participation in structured resistance exercise program
• Previous participation in a 13C amino acid tracer study within the last year
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6224 |
| NTR-old | NTR6380 |
| Ander register | : METC 163055 |