Does removal of allogeneic white blood cells by filtration reduce postoperative complications?
ID
Bron
Verkorte titel
Aandoening
The study population exists of major, non-cardiac surgery patients, who are expected to need > 3 units of red blood cell transfusions.
Ondersteuning
<br><br>
2. Sanquin Blood supply.
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Postoperative:<br>
1. In-hospital mortality;<br>
2. Duration of intensive care stay.
Achtergrond van het onderzoek
The aim of the study is to compare postoperative complications in patients undergoing major surgery who received non-filtered or filtered red blood cell transfusions.
No significant differences were found in mortality (odds ratio for filtered v non-filtered 0.80, 95% confidence interval 0.53 to 1.21) and in mean stay in intensive care (- 0.4 day, - 1.6 to 0.6 day). In the filtered group the mean length of hospital stay was 2.4 days shorter (- 4.8 to 0.0 day; P = 0.050) and the incidence of multi-organ failure was 30% lower (odds ratio 0.70, 0.49 to 1.00; P = 0.050).
There were no differences in rates of infection (0.98, 0.73 to 1.32).
Conclusion:
The use of filtered transfusions in some types of major surgery may reduce the length of hospital stay and the incidence of postoperative multi-organ failure.
Doel van het onderzoek
Does removal of allogeneic white blood cells by filtration reduce postoperative complications?
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Transfusions of filtered red blood cell concentrates vs. transfusion of stored buffy coat depleted red blood cell concentrates.
Publiek
P.O. Box 2184
J.A. Hilten, van
Leiden 2310 CD
The Netherlands
+31 (0)71 5685060
Joost.vanhilten@bloodrtd.nl
Wetenschappelijk
P.O. Box 2184
J.A. Hilten, van
Leiden 2310 CD
The Netherlands
+31 (0)71 5685060
Joost.vanhilten@bloodrtd.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Acute aneurysm-, elective aneurysm-, orthopaedic- and large gastro-intestinal surgery patients.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Under 18 years of age;
2. Transfusions received within 3 months prior to inclusion;
3. Pre existing medical indication for filtered red blood cell transfusions.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL271 |
| NTR-old | NTR309 |
| Ander register | : N/A |
| ISRCTN | ISRCTN48093674 |
Samenvatting resultaten
2. Ned Tijdschrift voor Hematologie 2005;
2:140-7