To analyse the diagnostic and prognostic value of plasma EV protein/miRNA and gene expression profiles of circulating cells for objectified ischemic coronary artery disease in patients with symptoms (e.g. chest pain) suggestive of coronary artery…
ID
Bron
Verkorte titel
Aandoening
angina pectoris; myocardial ischemia; suspected coronary artery disease (SCAD);
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Parameter; Extracellular vesicle protein- and miRNA-concentration, and gene expression profiles in circulating cells. <br>
Endpoint: Objectified ischemic coronary artery disease, determined by radionuclide myocardial perfusion imaging (Rubidium-82).
Doel van het onderzoek
To analyse the diagnostic and prognostic value of plasma EV protein/miRNA and gene expression profiles of circulating cells for objectified ischemic coronary artery disease in patients with symptoms (e.g. chest pain) suggestive of coronary artery disease.
Onderzoeksopzet
- Blood collection (60cc) at the day of inclusion.
- Follow-up assessment at 1 month, 1 year and 2 years after inclusion.
Onderzoeksproduct en/of interventie
None. The study has a prospective (diagnostic and prognostic) observational design. At the day of inclusion 6 tubes of venous blood (60cc in total) will be withdrawn from the intravenous peripheral access (canula) that is already inserted due to the rMPI protocol.
Publiek
Ingrid E.M. Bank
Maatweg 3
Amersfoort 3813 TZ
The Netherlands
Telephone: 0031-33-8502468
iem.bank@meandermc.nl
Wetenschappelijk
Ingrid E.M. Bank
Maatweg 3
Amersfoort 3813 TZ
The Netherlands
Telephone: 0031-33-8502468
iem.bank@meandermc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Patients in the cardiology outpatient clinic of the Meander Medical Center Amerfoort being evaluated because of suspected ischemic coronary disease, who will undergo radionuclide myocardial perfusion imaging (rMPI), as indicated by the treating cardiologist.
- Age > 18yr
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Patients from whom no informed consent is obtained
- Incapacitated adults: language barriers or other obstacles for full understanding of the study objectives
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5078 |
| NTR-old | NTR5210 |
| Ander register | NL48721.100.14 : TWO 14-25 |