To determine whether doubling the dose of corticosteroid injections in the treatment of arthritis in knee joints is more effective, both in number of responding patients and in duration of response (pain relief).
ID
Bron
Verkorte titel
Aandoening
triamcinolon
triamcinolone
arthritis
RA
kenacort
Ondersteuning
Zilvermeeuw 1,
7609 PP Almelo
+31(0)546 693 693
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Percentage of patients with sustained good response.
Achtergrond van het onderzoek
Injections of corticosteroids are widely practised in rheumatology. Different kinds of corticosteroids are being used for local injection. Although local corticosteroid injections are widely practised, there are only few studies published in relationship with the response on the therapy. Factors predicting the response in pain relief of local corticosteroid injections are therefore largely unknown. A clinical dose-effect relationship has not yet been properly studied. The amount of drug being dosed is currently determined by clinical tradition.
Doel van het onderzoek
To determine whether doubling the dose of corticosteroid injections in the treatment of arthritis in knee joints is more effective, both in number of responding patients and in duration of response (pain relief).
Onderzoeksopzet
t = 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 weeks.
Onderzoeksproduct en/of interventie
Patients will receive 40 or 80 mg triamcinolone (Kenacort) to determine whether doubling the dose of corticosteroid injections in the treatment of arthritis in knee joint is more effective in the relief of symptoms.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Arthritis patients, RA or other causes of chronic arthritis (not osteoarthritis and not gout) with an indication for local injection with corticosteroid due to active arthritis in knee joint;
2. Patients should have stable anti-arthritic co-medication.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Contraindication for local injection with corticosteroid (infection, relevant skin lesion, uncontrolled diabetes mellitus);
2. Chronic (>3 months) or current use of more than 10mg prednisolone or equivalent daily;
3. No informed consent.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2174 |
| NTR-old | NTR2298 |
| Ander register | METC Enschede : P10-10 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |