We hypothise that women with a history of preeclampsia have accelerated vascular aging in comparison with control women with uncomplicated pregnancies.
ID
Bron
Verkorte titel
Aandoening
Preeclampsia, cardiovascular disease, renal function, hemodynamics
Pre-eclampsie, hart- en vaatziekten, renale functie, hemodynamiek
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Renal vascular resistance.
Achtergrond van het onderzoek
Preeclampsia is associated with an increased risk on the development of cardiovascular and renal disease. It seems that similar risk factors are both predictive for preeclampsia and cardiovascular disease. We hypothise that women with a history of preeclampsia have accelerated vascular aging in comparison with controls. Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls. This is a longitudinal case-control study in which 20 formerly preeclamptic women and 10 controls will be included. Those women are recruited from a previous study performed in the period of 1996-1999. The same measurements, including blood pressure, PAH/inulin clearance, plasmavolume, arterial/venous compliance and echocardiography, will be performed.
Doel van het onderzoek
We hypothise that women with a history of preeclampsia have accelerated vascular aging in comparison with control women with uncomplicated pregnancies.
Onderzoeksopzet
One day.
Onderzoeksproduct en/of interventie
None; observational case-control study.
Publiek
Secr. Obstetrie/gynaecologie
Postbus 5800
T. Ekhart
Maastricht 6202 AZ
The Netherlands
+31 (0)43-3882101
T.Ekhart@og.unimaas.nl
Wetenschappelijk
Secr. Obstetrie/gynaecologie
Postbus 5800
T. Ekhart
Maastricht 6202 AZ
The Netherlands
+31 (0)43-3882101
T.Ekhart@og.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Participation in previous study period 1996-1999. Women with a history of preeclampsia and/or HELLP syndrome. Control women with uncomlicated pregnancies. Previous research within 3 years after pregnancy.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Pre-existent hypertension.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1567 |
| NTR-old | NTR1647 |
| Ander register | MEC : 08-2-130 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |