Nocturnal FFA levels are higher in obese insulin resistant subjects and are less sensitive to the FFA lowering effects of a â-receptor blocker.
ID
Bron
Verkorte titel
Aandoening
free fatty acid release
vrije vetzuur afgifte
Ondersteuning
P.O. Box 22660
1100 DD
Amsterdam
The Netherlands
+31 (0)20 5669111
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Percent and/or absolute changes in nocturnal FFA levels with or without â-blockage.
Achtergrond van het onderzoek
It has been convincingly demonstrated that free fatty acids (FFA) play a key role in the induction of obesity-induced insulin resistance. The higher plasma levels of FFA originate from adipocytes which show higher rates of lipolysis in insulin stimulated states, i.e. insulin resistance of adipose tissue. The release of FFA is pulsatile and show a circadian rhythm and is thereby in part controlled by the central nervous system. Whether this pulsatility or rhythm is disturbed in insulin resistant subjects is not known. In a dog model FFA levels can be lowered by blocking the â-receptor present on the adipocyt, thereby decreasing the influence of the central nervous system on FFA release. In this study we aim to translate these findings to obese insulin resistant and lean insulin sensitive humans.
Doel van het onderzoek
Nocturnal FFA levels are higher in obese insulin resistant subjects and are less sensitive to the FFA lowering effects of a â-receptor blocker.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Propranolol infusion
Publiek
Department of Endocrinology and Metabolism <br>
P.O. Box 22660<br> 1100 DD
B.A.M. Weijer, de
Meibergdreef 9 (F5-177)
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666849
B.A.deWeijer@amc.uva.nl
Wetenschappelijk
Department of Endocrinology and Metabolism <br>
P.O. Box 22660<br> 1100 DD
B.A.M. Weijer, de
Meibergdreef 9 (F5-177)
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666849
B.A.deWeijer@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Male obese subjects (BMI > 30 kg/m2) and healthy lean controls (BMI 20 > 25 kg/m2)
2. Age 20 – 50 years
3. Stable weight 3 months prior to study inclusion
4. Caucasian
5. Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Any chronic medical condition or use of any medication
2. Asthma and bronchospastic COPD
3. Tobacco use
4. Alcohol abuse (>3/day)
5. Frequent intensive exercise (>2 week)
6. Familial lipid disorders, renal insufficiency (creatinine > 150 umol/L) , elevated liver enzymes (> 2 times), hypertension
7. Hypotension (BP < 100/60 mmHg), bradycardia (HR < 60min)
8. Unwilling or unable to provide informed consent
9. First degree family members with diabetes
10. Abnormal day/night rhythm (shiftworkers etc)
11. Blood donation in the past three months
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