During the pandemic wave the immunity against COVID-19 will build up across the different age groups in The Netherlands.
ID
Bron
Verkorte titel
Aandoening
COVID-19, SARS-CoV-2
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To assess achieved immunity against COVID-19 across the different age groups in The Netherlands by testing a representative part of
the Dutch population for the presence of SARS-Cov-2 specific antibodies in serum
Achtergrond van het onderzoek
The first person infected with the novel coronavirus, SARS-CoV-2, that presented with COVID-19 disease, emerged on November 2019
in Wuhan, China. Since then, the virus has spread worldwide, with new cases emerging every day. The first COVID-19 case in the
Netherlands was confirmed on February 27, 2020. At this moment, the scope of undetected spread of the virus, the fraction of immune
persons due to recent infection, and the course of further spread within the Netherlands is largely unknown. Since, the spreads rapidly,
laboratory testing of all suspected cases is not feasible anymore. The sera, collected in the previous PIENTER 3 study, provides an
unique opportunity to function as baseline for antibody levels against SARS-CoV-2 of the Dutch population prior to the COVID-19
pandemic. In the present study proposal, PIENTER 3 participants, that had previously indicated that they could be approached for a
follow-up study, will be asked to donate a finger prick blood sample by self-sampling and fill in a questionnaire at different time points
during and after the coronavirus pandemic in the Netherlands. This follow-up sampling will obtain insight in the obtained humoral
immunity against SARS-CoV-2 during this first pandemic wave in the Netherlands. This is important to monitor the status of the
generated immunity against SARS-CoV-2 as well as to identify possible gaps among different age groups in The Netherlands, to identify
risk groups that are not immune. Furthermore, data from this study can contribute to the evaluation of recently implemented intervention
measurements by policy makers and to take decisions for new measurements needed). In addition, it may provide clues how the
pandemic will evolve; can we get the pandemic under control, can we stabilize it, or can we expect a new pandemic period?
Amendment 1: In addition to the previous PIENTER 3 participants, another approximately 13,600 subjects will be invited to obtain seroprevalence data from a larger sample with more municipalities included. This will provide a more complete picture of seroprevalence of COVID-19, especially considering the geographic clustering of COVID-19 a wider geographic spread is desirable. Furthermore, this allows us to detect minor changes in antibody levels among particular subgroups (1-3%), such as age groups, but also minor changes in time when antibody levels from samples taken at different time points are compared. Furthermore, it enables us to have information from the whole country, including geographically areas that were not sampled in the previous sampling frame. With both groups we estimate to reach an inclusion of ~7000 participants.
Amendment 5: follow-up of the trial to a maximum of 15 fingerprick bloods in 5 years. For the follow-up all existing participants can participate, additionally 66.000 new subjects are invited to participate.
For more information about the previous study: PIENTER3 study (NL5467 / NTR5611).
Doel van het onderzoek
During the pandemic wave the immunity against COVID-19 will build up across the different age groups in The Netherlands.
Onderzoeksopzet
The intention is to collect serum samples and questionnaire data over a time period of 5 years, with a maximum of 15 different sampling time points, guided by the epidemiology of the pandemic (reporting rates). The first timepoint for sampling will be as soon as possible, thereafter sampling moments will be chosen based on epidemiological information.
Onderzoeksproduct en/of interventie
Not applicable
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Subject previously participated in the PIENTER 3 study (2016/17) and had indicated that they could be approached for a follow-up study, or Subjects from a random age-stratified sample from the Netherlands
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
There are no exclusion criteria.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL8473 |
CCMO | NL73474.100.20 |
OMON | NL-OMON52416 |
Samenvatting resultaten
https://pubmed.ncbi.nlm.nih.gov/33624751/
https://pubmed.ncbi.nlm.nih.gov/33249407/
https://pubmed.ncbi.nlm.nih.gov/33772265/
https://pubmed.ncbi.nlm.nih.gov/34114187/