18F-Fluciclatide PET imaging can detect colorectal and pancreatic lesions.
ID
Bron
Verkorte titel
Aandoening
Pancreatic cancer, colorectal cancer.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Assess feasibility and sensitivity of imaging tumor angiogenesis in PDAC and colorectal adenocarcinoma, using 18F-Fluciclatide. When successful, the data of this study will allow for a larger trial.
Achtergrond van het onderzoek
18F-Fluciclatide PET imaging in colorectal and pancreatic cancer detection.
Doel van het onderzoek
18F-Fluciclatide PET imaging can detect colorectal and pancreatic lesions.
Onderzoeksopzet
.
Onderzoeksproduct en/of interventie
18F-Fluciclatide PET scan
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Biopsy proven primary colorectal adenocarcinoma or suspected pancreatic ductal adenocarcinoma, as agreed on by multidisciplinary team;
No prior chemo(radio)therapy in rectal cancer patients.
Patient scheduled to undergo surgery;
Patients treated in the LUMC.
Before patient registration, written informed consent must be given according to ICH/GCP, and national/local regulations
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Contraindication for PET (pregnancy, breast-feeding and severe claustrophobia);
Impaired renal function (creatinine clearance < 60 mL/min according to the CockcroftGault equation or ureum < 2x ULN (Upper limit of normal);
Impaired liver function (ALAT, ASAT > 3 ULN or total bilirubin >2x ULN);
Known allergy to pABA (p-aminobenzoate sodium salt);
Presence of any psychological, familial, sociological or geographical conditionpotentially hampering compliance with the study protocol and follow-up schedule;
Inability to tolerate lying supine for the duration of a PET/CT examination (~30min).
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7605 |
| Ander register | METC LUMC : P18.210 |