The aim is to evaluate molecular assays for the detection and quantification of bacterial DNA in blood from patients with bacteraemia.
ID
Bron
Verkorte titel
Aandoening
Sepsis
Bacteraemia/ bacteremia
Molecular diagnosis bacteria in blood
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Primary objectives: <br>
1. To determine the diagnostic performance of five molecular assays for the detection of bacteraemia in patients. <br>
2. To evaluate the relationship between the bacterial DNA load (BDL), quantitative culture and culture time-to-positivity in patients with bacteraemia.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
The aim is to evaluate molecular assays for the detection and quantification of bacterial DNA in blood from patients with bacteraemia.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
N/A
Publiek
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Wetenschappelijk
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age >= 18 years ;
- Bacteraemia with at least one blood culture with growth of Gram-negative bacteria or Gram-positive cocci in chain observed with microscopy;
- Bacteraemia with at least one blood culture with growth of Gram-positive cocci (in clusters) and at least one of the following syndromes suggestive of S. aureus infection: arthritis, wound infection, thrombophlebitis, meningitis, soft tissue infection, vertebral osteomyelitis, splenic abscess or other microbiological evidence for S. aureus infection.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Blood culture obtained >48 hours;
- Intravenous antibiotic therapy >48 hours;
- Haematological disorder;
- Anaemia (an Hb below 5.5 mmol/L);
- Participation in BLENT-study of patients with endocarditis;
- Previous participation in this study
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3932 |
| NTR-old | NTR4094 |
| Ander register | : 12277 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |