Influence of lactate on the brain and lipid metabolism.

Healthy participants inclusion:

1. Male;

2. BMI < 26 kg/m2;

3. Age 18-65 yrs;

4. Normal HbA1c level;

5. Normal renal and liver function (creatinine < 150 umol/L, normal liver enzymes);

6. Not on any medication affecting glucose or lipid metabolism or affecting brain regulation (anti-depressants/anti-convulsants);

7. Alcohol intake less than 2 units per day;

8. No claustrophobia in the view of the MRS;

9. No foreign metal devices in the view of the MRS;

10. No panic disorder.



Inclusion criteria for people with FCH:

1. FCH patients meet the criteria of the nomogram of Veerkamp(37);

2. Inclusion criteria 3-9 are identical to healthy participants;

3. Males, matched with healthy participants for age;

4. BMI<27 kg/m2;

5. Triglyceride levels >2.5 mmol/l;

6. No relevant active disease;

7. No known cardiovascular disease;

8. No statins intake for at least 6 weeks.

Medication influencing the brain.