Impairment of immune-complex-induced neutrophil activation caused by PDE4 inhibition, making it a potential target for the treatment of pemphigoid diseases.
ID
Bron
Verkorte titel
Aandoening
Pemphigoid
Pemfigioid
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Partial remission
Achtergrond van het onderzoek
Pemphigoid is the most common chronic autoimmune disease of the skin and mucosae. It is often treated with systemic corticosteroids, which are associated with serious adverse effects. Therefore, there is a need for safer treatment options. In this pilot efficacy study the treatment response of apremilast combined with doxycycline in mild to moderate cutaneous pemphigoid of ten patients will be evaluated. The primary objective is partial remission, secondary objectives are drug survival and complete remission. Eligible patients will be recruited during routine clinical care in the department of Dermatology of the UMCG.
Doel van het onderzoek
Impairment of immune-complex-induced neutrophil activation caused by PDE4 inhibition, making it a potential target for the treatment of pemphigoid diseases.
Onderzoeksopzet
Baseline and week 16
Onderzoeksproduct en/of interventie
Apremilast combined with doxycycline
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Adult patients with recently diagnosed mild to moderate localized or generalized cutaneous pemphigoid, or patients that were in complete remission without treatment that have a mild-moderate flare-up of the disease.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Contradiction or known allergy for PDE4 inhibitors.
Women of childbearing potential without contraception, women who are pregnant or planning to become pregnant or who are lactating.
Patients that use systemic immunosuppressive medication
Any condition which would make the patient unsuitable for treatment, or requires steroid use.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7166 |
| NTR-old | NTR7388 |
| Ander register | Celgene : AP-CL-OTHER-PI-12868 |