Effects of a single denosumab injection on reduction of total contact cast treatment and consolidation of bonefractures caused by acute Charcotfoot in patients with diabetes mellitus (CHARCOT study)

we will investigate whether a single dose of denosumab injection sc will have a beneficial effect compared to placebo on time in contact cast (duration), bone quality improvement (radiological) and foot form conservation in patients with acute charcot foot . Also improvement in clinical riskscore variables and plasma markers of bone turnover will be studied.

single denosumab injection has a beneficial effect on shortening time in contact cast and foot form preservation in DM subjects with an acute charcot foot

0,3,6 and 9 months

single denosumab injection 60mg vs placebo injection subcutaneous